Journal of Bioanalysis & Biomedicine

ZhongMao Guo

Publications

• Research Article
  Apolipoprotein E-Deficient Lipoproteins Induce Foam Cell Formation by Activation of PERK-EIF-2�Ž�± Signaling Cascade
  Author(s): YanFeng Zhao, ZhongMao Guo, XingHua Lin, LiChun Zhou, Emmanuel U. Okoro, GuoHuang Fan, Raju Ramaswamy and Hong YangYanFeng Zhao, ZhongMao Guo, XingHua Lin, LiChun Zhou, Emmanuel U. Okoro, GuoHuang Fan, Raju Ramaswamy and Hong Yang
  
  Transformation of macrophages into foam cells by apolipoprotein (Apo) E-de fi cient, ApoB48-containing (E Ã?â??Ã?¾ /B48) lipoproteins has been shown to be associated with increased phosphorylation of eukaryotic initiation factor-2 α (eIF- 2 α ). The present report examined the causal relationship between eIF-2 α phosphorylation and lipid accumulation in macrophages induced by E Ã?â??Ã?¾ /B48 lipoproteins. E Ã?â??Ã?¾ /B48 lipoproteins increased eIF-2 α phosphorylation and cholesterol ester accumulation, while lipoprotein degradation decreased and lysosomal acid lipase and cathepsin B mRNA translation was inhibited in mouse peritoneal macrophages (MPMs). These responses were overcome by overexpression of a nonphosphorylatable eIF-2 α mutant in MPMs. Incubation of MPMs with E Ã?â??Ã?¾ /B48 li.. Read More»
  DOI: 10.4172/1948-593X.1000033

  Abstract PDF