Journal of Nephrology & Therapeutics

Zhuo Shi

Publications

• Research Article
  Children with Nephrotic Syndrome Suffer from Cerebral Venous Thrombosis
  Author(s): Zheng-Kun Xia, Tao Sun, Zhuo Shi, Hongjun Peng, Min Xu, Xiao Yang, Zhongmin Fan, Yuanfu Gao, Chunlin Gao, Jing Li, Xu He and Pei ZhangZheng-Kun Xia, Tao Sun, Zhuo Shi, Hongjun Peng, Min Xu, Xiao Yang, Zhongmin Fan, Yuanfu Gao, Chunlin Gao, Jing Li, Xu He and Pei Zhang
  
  Hypercoagulability is a common complication in children with nephrotic syndrome and may cause venous thrombosis. This study explored the effectiveness of urokinase and low-molecular-weight (LMW) heparin used in conjunction in seven children with nephrotic syndrome complicated by intracranial venous thrombosis. The urokinase dose was 2,000-4,000 u/kg/day initially, with a pulse dose of 20,000-40,000 u given within 15-30 minutes and the remainder was pump-infused. From day 2, a dose of 2,000 u/kg/day was infused via the pump, and the total course duration was 3 to 7 days. During treatment, thrombin time (TT) and activated partial thromboplastin time (APTT) were tested three times per week, and particular attention was given to any bleeding. LMW heparin was used at a dosage of 100-120 anti-Xa IU/kg once or twice per day, given by abdominal subcutaneous inject.. Read More»
  DOI: 10.4172/2161-0959.S11-005

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