Medicinal Chemistry

Zhuo Wang

Publications

• Research Article
  Pharmacokinetics of Cycloserine in Rats by HPLC-MS/MS
  Author(s): Liping Yan, An Xie, Zhuo Wang, Wenjing Zhang, Yi Huang and Heping XiaoLiping Yan, An Xie, Zhuo Wang, Wenjing Zhang, Yi Huang and Heping Xiao
  
  Objective To investigate the pharmacokinetics of cycloserine in healthy rat blood and lung tissues. Method Healthy rat blood and lung tissues were sampled in vivo by microdialysis sampling technique simultaneously. The concentrations of cycloserine in both blood and lung tissues were measured by high performance liquid chromatography mass spectrometry. All data were analyzed by Win Nonlin software. Results:The maximum concentration of free cycloserine in blood and lung tissue were (10.61 ± 2.42) mg/L and (1.53 ± 1.71) mg/L at 1h. And then both continued to decline. After administration the concentrations of free cycloserine in the blood has been higher than the concentrations in lung tissues. The area under the concentration curve (AUC) of free cycloserine was (33.53 ± 6.51) h·mg-1·L-1 in blood, and (4.49 ± 2... Read More»
  DOI: 10.4172/2161-0444.1000250

  Abstract PDF