Journal of Antimicrobial Agents

Department of R and D, MC-Development LLC, Moscow, Russia

Publications

• Research Article   
  Immune-mediated Effects of Lactitol in Animals with Antibiotic-induced Dysbiosis after Infection with Clostridium Difficile
  Author(s): A. Sergeev*, N. A. Mnafki, E. A. Ryabenko, A. A. Nikitina, C. Shammas, E. Nikolaou, A.V. Dikovskiy, T.I. Kombarova, O. V. Korobova, E. A. Ganina, I. P. Mitsevits, A. I. Borzilov, M. V. Khramov and L. C. Zacharia
  
  The research objective was to study the effect of dysbiosis in mice and hamsters caused by the treatment with combination of amoxicillin trihydrate and potassium clavulanate on the colonization with Clostridium difficile (C. difficile) and course of C. difficile infection (CDI), to estimate the effect of the prebiotic lactitol when was administered with antibiotic for prevention and therapy of the CDI. CDI is a current public health problem. The combination of amoxicillin and clavulanic acid is considered an antibiotic with high risk of adverse CDI. Meanwhile, prebiotics as a substrate for bacteria, are able to normalize the composition of the microbiota damaged by antibiotics and could prevent CDI. It was found that lactitol in animals led to a significant 10-fold decrease in excretion of C. difficile from mice feces, and 2.5-fold decrease in feces of infected hamsters, compared with an.. Read More»
  

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