Journal of Hypertension: Open Access

Department of Neurology, University of Bergamo, 24129 Bergamo, Italy

Publications

• Mini Review   
  Renin-Angiotensin-Aldosterone System Pathways in Hypertension and Obese Adolescents
  Author(s): Aadya Shrokowa*
  
  The Renin-Angiotensin-Aldosterone System (RAAS) plays a pivotal role in regulating blood pressure and fluid balance, with both classical and alternative pathways contributing to its physiological effects. This review examines the involvement of RAAS pathways in the pathogenesis of hypertension and obesity in adolescents. Classical RAAS activation involves the conversion of angiotensinogen to Angiotensin II (Ang II), leading to vasoconstriction and aldosterone release, while alternative pathways, such as the Angiotensin-Converting Enzyme 2 (ACE2)/angiotensin-(1-7)/ Mas receptor axis, counterbalance these effects by promoting vasodilation and natriuresis. In obese adolescents, dysregulation of RAAS pathways contributes to hypertension through mechanisms including adipocyte-derived angiotensinogen, insulin resistance and sympathetic nervous system activation. Unde.. Read More»
  DOI: 10.37421/2167-1095.2024.13.444

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