Department of Internal Medicine, Sohag University Hospital, Egypt
Review Article
Autophagy: A New Horizon in Cancer Research
Author(s): Gebril SM, Abdelaal UM and Abu-Deif EE*
Oncophagy (cancer–autophagy interplay) became a focus of interest after awarding Yoshinori Ohsumi the Nobel
Prize for Physiology or Medicine for his work elucidating the mechanism of autophagy. One of the interesting hot
spots in the research work is the growing evidence of the fundamental role of autophagy in cancer. Autophagy is
degradation process, intimately intertwined with cellular metabolism, stress, genetic instability and cellular death.
Autophagy modulation could be a therapeutic rational for emerging cancer. We aim by this mini-review to precise
the role of autophagy in carcinogenesis whether it is with or against... Read More»
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