Medicinal Chemistry

Department of Chemistry, University of Washington, Seattle, WA 98195, USA

Publications

• Mini Review   
  Embracing Phenotypic Drug Discovery for Next-generation Therapeutics
  Author(s): Adhara Kaeli*
  
  Phenotypic drug discovery has emerged as a promising approach to identify novel therapeutics by focusing on the functional outcomes of drug action rather than specific molecular targets. This abstract explores the rationale behind phenotypic screening, highlighting its advantages in uncovering complex mechanisms of action, identifying unexpected targets and mitigating issues of target validation. Furthermore, it discusses recent advancements in phenotypic screening technologies, including high-throughput assays and computational approaches, which have accelerated the discovery of diverse compounds with therapeutic potential. By embracing phenotypic drug discovery, researchers can harness the complexity of biological systems to develop innovative treatments for a wide range of diseases, ultimately paving the way for next-generation therapeutics... Read More»
  DOI: 10.37421/2161-0444.2024.14.720

  Abstract HTML PDF