Pulmonary & Respiratory Medicine

Divisions of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

Publications

• Research   
  Heterogeneity of Chronic Lung Allograft Dysfunction Phenotypes: Spirometric, Histopathologic and Imaging Associations over a 16-Year Experience
  Author(s): Silvia Coronel, Shamili Allam, Neha Teekappanavar, Ahmed Abdelhalim, Sivagini Ganesh, Wafaa Elatre, Michael Koss, Janice Liebler, Richard Barbers, Alison Wilcox, Bonnie Garon, Zea Borok, Billy Peng and Ahmet Baydur*
  
  Background: The 2019 update by the ISHLT of classification for CLAD includes a mixed and undefined phenotype. Objectives: Assess (a) frequency phenotypes (per ISHLT) with emphasis on double lung transplants (DLTxs), (b) concordance spirometry with imaging and transbronchial biopsy findings, (c) mortality rates amongst phenotypes. Methods: Single-center retrospective study of adult patients. Time from transplant to CLAD and mortality amongst phenotypes compared by ANOVA adjusted for age, gender and BMI. Results: Of 360 patients, 96 (27%) met criteria for CLAD (57 DLTx). Seventy-four (77%) experienced combined FEV1 and FVC decline. In DLTxs, onset of FEV1 decline (n=12) occurred 10 months earlier than for FVC (n=4) and 5 months before simultaneous onset of FVC and FEV1 decline (n=41). Among.. Read More»
  DOI: 10.37421/2161-105X.2021.11.522

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