Department of Public Health and Community Medicine, King Saud University, Riyadh, Saudi Arabia
Research Article
Cyclosporine Nephrotoxicity in Patients with Type 1 Diabetes Mellitus Arbitrary Verdict: A Meta-Analysis of Randomized Control Trials
Author(s): Ahmed M El-Malky* and Ramachandra G Naik
Background: Disturbance in renal function was considered to be a common complication of Cyclosporine-A (CsA) treated patients of
recent-onset type 1 diabetes mellitus, for purposes of remission. The aim of the present study was to scrutinize the potential association
between this drug and its complications by conducting a meta-analysis of randomized control trials.
Methods: A consummate literature search of PubMed, EMBASE, and web of science was conducted until March 2019. A total of 9 randomized
control trials were included in this meta-analysis.
Results: On meta-analysis of nine studies evaluating the risk of transient complications, analysis of the random effect of 12 months-low
dose-cyclosporine on serum creatinine, revealed the absence of CsA induced nephrotoxicity. And no association between CsA and r.. Read More»
DOI:
10.37421/2475-3211.2023.8.205
Journal of Diabetic Complications & Medicine received 102 citations as per Google Scholar report