Biosensors & Bioelectronics

Department of Mechanical Engineering, Cambridge University, London, UK, Cambridge University Hospitals UK, UK

Publications

• Commentary   
  Assessment of the Diagnostic Accuracy of Three Commercial Interferon-gamma Release Assays for Mycobacterium tuberculosis
  Author(s): Akamatsu Yusuke*
  
  The diagnostic accuracy of interferon-gamma release assays for detecting Mycobacterium tuberculosis infection has been a focal point of tuberculosis diagnostics, especially given the limitations of traditional methods like the tuberculin skin test. IGRAs measure the release of interferon-gamma from sensitized T-cells in response to specific Mtb antigens, providing a more specific and reliable diagnostic tool for both latent tuberculosis infection and, to some extent, active TB. These assays were assessed for their sensitivity, specificity, and overall diagnostic accuracy under varying clinical and demographic conditions. The study enrolled a diverse cohort of participants, including individuals with confirmed active TB, those with presumed latent TB infection, and healthy controls with no history of TB exposure. Participants included adults and children from high-burden and low-b.. Read More»
  DOI: 10.37421/2155-6210.2024.15.474

  Abstract HTML PDF