Clinical and Medical Case Reports

Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy, Sapienza University of Rome, Italy

Publications

• Perspective   
  Hemoadsorption in Viscerocutaneous Loxoscelism-Related Multiorgan Failure
  Author(s): Alcides Jorge*
  
  Hemoadsorption in viscerocutaneous loxoscelism-related multiorgan failure represents a critical area of exploration within modern medicine. Viscerocutaneous loxoscelism, a severe complication of envenomation by Loxosceles spiders (commonly known as recluse spiders), is characterized by systemic inflammation and tissue necrosis that can progress to multiorgan failure. While supportive care remains the mainstay of treatment, hemoadsorption has emerged as a promising therapeutic modality. This essay examines the pathophysiology of viscerocutaneous loxoscelism, the role of hemoadsorption, and its potential to mitigate the progression of multiorgan fail. Loxoscelism results from the bite of Loxosceles spiders, which inject complex venom containing various proteins and enzymes. Among these, sphingomyelinase D is considered the most critical, as it induces dermonecrosis, platelet aggregation.. Read More»
  DOI: 10.37421/2684-4915.2024.8.341

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