Clinical Research Development Unit, Ghaem Hospital, Ahmadabad Street, Mashhad, Iran
Research
Fabrication, Characterization and Optimization of Multiphasic Zein/Cartilage-derived Matrix/CP/Gelatin Composite Scaffolds for Potential Bone Tissue Engineering Applications
Author(s): Azadeh Shahroodi, Sogol Hooshyar, Davood Yari, Jebraeil Movaffagh and Ali Moradi*
Introduction: Creating an ideal scaffold for bone tissue engineering requires specific characteristics. Composite materials, combining the
advantages of polymers and ceramics, offer tailored properties and enhanced functionality. This study aimed to fabricate, characterize and optimize
multi-phasic composite scaffolds with spiral backbones for potential bone tissue engineering applications.
Methods: Composite scaffolds were fabricated via electrospinning using 24.5% Zein and varying concentrations of Calcium Phosphate (CP) (15%,
20% and 25%). Ribbon-shaped electrospun Zein/CP composite mats were structured into spiral forms, placed in cylindrical Teflon molds, filled
with a blended slurry (Zein/cartilage-derived matrix/CP/gelatin), snap-frozen and lyophilized to form multi-phasic composite scaffolds. Mechanical,
FESEM and FTIR a.. Read More»
DOI:
10.37421/2157-7552.2024.15.351
Journal of Tissue Science and Engineering received 807 citations as per Google Scholar report