Journal of Cytology & Histology

The International Center for Training and Advanced Researches (ICTAR-Egypt), Cairo, Egypt

Publications

• Research Article   
  Use of Secondary Metabolites Derived from Aspergillus Species as Anticancer Agents and Related Histological and Genetic Alterations: In Vitro Study
  Author(s): Mohammad Y Alfaifi, Tamer MM Abuamara, Mohamed E Amer, Mohamed SM Nasr, Wagih M Abd-Elhay, Laila E EI Moselhy, Tamer Albasyoni Gomah, Serag Eldin I Elbehairi, Harbi Ali Ali and Aly Fahmy Mohamed*
  
  The present work aimed to use natural derived fungal secondary metabolites as anticancer agents concerning cytotoxicity, apoptotic, genetic and histopathological profile. It was noticed that Asp. Terrius (Asp. T), Flavous (Asp. Fl) and Fumegatgus (Asp. Fu) induced variable toxic potential that was cell type, secondary metabolite type and concentration dependent. CaCo-2 cells showed less sensitivity than HuH-7 and in turn the IC50 was variable. Also, the apoptotic potential of Asp. species derived fungal secondary metabolites was proven via detection of up regulated pro apoptotic genes and down regulation of anti-apoptotic genes. The expression rate was cell type dependent. Concurrently apoptotic profile was accompanied with cellular DNA accumulation at the G2/M phase, an insignifica.. Read More»
  DOI: 10.37421/jch.2020.11.552

  Abstract HTML PDF