Journal of Clinical Case Reports

Department of Laboratory Medicine, Institute of Biomedicine, The Sahlgrenska Academy and Sahlgrenska University Hospital, Gothenburg University, Gothenburg, Sweden

Publications

• Case Report   
  A Novel Treatment Combination of Sildenafil, Mepivacaine and Glucose with Disease Modifying Properties, In a Pony with Lameness Associated Osteoarthritis: A Case Report
  Author(s): Eva Skiöldebrand*, Kristin Abrahamsson Aurell, Saritha Adepu, Anders Lindahl and Elisabeth Hansson
  
  Today no biomarkers reflecting joint tissue destruction or Disease-Modifying Osteoarthritis Drugs (DMOADs) are available on the market. This case report decscribes a new pharmaceutical drug combination consisting of Sildenafil, Mepivacaine and Glucose (SMG) used for intra-articular treatment of lameness associated osteoarthritis of the right distal interphalangeal joint in a nine-year-old Swedish pony. The pony had a history of moderate lameness during five months and were treated with intra articular corticosteroids three times without any recovery of lameness (visit 1-5). Clinical lameness examinations, including intra articular anaesthesia, radiological examination, standing low-field MRI and quantification of biomarkers for cartilage and bone degradation (COMP156 and BGN262) in synovial fluid and serum was performed over a period of 24 mon.. Read More»
  DOI: 10.37421/2165-7920.2023.13.1576

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