Clinical and Medical Case Reports

Department of Pathology, Emory University, Atlanta, Georgia, USA

Publications

• Mini Review   
  Cancer Macrophages are Present in Endometrial Cancers: A Mini Review
  Author(s): Angela Behera*
  
  The complex tumour microenvironment is a crucial regulator of anti-tumor immune responses in gynecologic cancers. How cancer cells interact with the diverse population of immune effector cells has a substantial impact on the efficacy of traditional chemotherapy and cutting-edge immunotherapy methods. In this study, we focus specifically on the role of macrophages in ovarian, endometrial, and cervical cancers. We discuss the evolution of macrophages and how their polarisation status is influenced by the stimuli in their surroundings. By fostering tumour growth and controlling immune-suppression, tumor-associated macrophages (TAMs) in the tumour microenvironment affect treatment outcomes. We outline clinical strategies that particularly target TAMs, such as limiting macrophage differentiation, blocking immunological checkpoints, reducing monocyte recruitment to the tumour, and preventin.. Read More»
  DOI: 10.37421/2684-4915.2022.6.214

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