Neurological Disorders

Immanuel Kant Baltic Federal University/School of Life Sciences, Russia

Publications

• Value Added Abstracts   
  Changes in the GABAergic signalling in the prefrontal cortex of mice model of posttramautic stress disorder
  Author(s): Arina Serbina
  
  It has been suggested that the neurons of prefrontal cortex, along with the hippocampus and amygdala, can undergo morphological and molecular remodeling during the development of stress-related disorders, such as PTSD. Pathological remodeling of the GABAergic inhibitory signalling during stress disorders might bring significant contribution to impairment of synaptic plasticity and cognition. In this work we have used an experimental model of PTSD in mice, based on a single prolonged stress protocol and studied alterations in the synaptic transmission and long-term synaptic plasticity in the pyramidal neurons of prefrontal cortex. The stress state in the animals was evaluated with the aid of open field and elevated cross-maze behavioral tests. We have found an increase in the quantal amplitude of GABAergic spontaneous inhibitory s.. Read More»
  

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