National Cancer Institute, Cairo University, Giza, Egypt
Research Article
In silico Docking for Inhibition Neuropilin-1 (Sars-Cov-2 Receptor) by Some Natural Compound and Approved Drugs
Author(s): Mohamed Gomaa Seadawy*, Mohamed Shamel Eldesoky, Aya Ahmed and Abdel Rahman Nabwi Zekri
Background: Neuropilin-1 (NRP-1) is a multifunctional transmembrane receptor for ligands that affect developmental axonal growth and angiogenesis. Beside
its role in cancer, NRP-1 is a reported entrance for several viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent
of coronavirus disease 2019 (COVID-19).
Methods: We made Insilco docking between the spike protein and Neuropilin-1 using Cluspro 2.0 software. Therefore, Neuropilin-1 becomes host factor for SARSCoV-
2 infection. Then by using molecular docking, we test nine compounds against Neuropilin-1 for its inhibition.
Results and Conclusion: Our study revealed that some drugs and natural compounds success in inhibition of binding between the virus and its new receptor
with Insilco docking data... Read More»
Virology: Current Research received 187 citations as per Google Scholar report
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