Department of Medical Sciences, Ladoke Akintola University of Technology, Oyo State, Nigeria
Research
The Effect of Dietary Co-enzyme Q10 Supplementation on Haematological Parameters and Splenic Morphology in Mouse Model of 5-Fluorouracil-Induced Toxicity
Author(s): Ayomiposi Akanmu Oluwatosin*
Coenzyme Q10 (CoQ10) antioxidant strength has been seen in many studies. Most chemotherapy have been seen to cause side effect through oxidative stress. This work seeks to study the ability of CoQ10 to counter the oxidative stress and thus remediate the chemotherapy induced toxicities of chemotherapeutic agents.
Fifty male mice were used for this study. They were divided into 5 groups (of 10 rats each) which include normal control (standard diet plus intraperitoneal (i.p) normal saline), 5 Fluorouracil (5FU) control (negative control) (standard diet plus i,p 5 fluorouracil at 200 mg/kg body weight) and three treatment groups of CoQ10 incorporated into standard diet at 100 mg/kg, 200 mg/kg and 400 mg/kg of feed of feed. The weight of the rats was measured every 3 days and recorded. The experiment lasted for two weeks after which the rats were euthanized by cervical dislocatio.. Read More»
DOI:
10.37421/2952-8100.2024.7.385
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