Journal of Lung Diseases & Treatment

Department of Translational Science, Florida International University, Port St. Lucie, FL 34987, USA

Publications

• Mini Review   
  Inhaled Drug Particle Dissolution and Absorption in the Lungs
  Author(s): Basanth Bastola*
  
  Dry powder inhalation therapy has been shown to be effective in treating localised lung diseases such as asthma, COPD, cystic fibrosis, and lung infections. The physicochemical nature and aerosol performance of powder particles are determined in vitro for dry powder formulations. There is a well-established relationship between particle properties (size, shape, surface morphology, porosity, solid state nature, and surface hydrophobicity) and aerosol performance of an inhalable dry powder formulation. In contrast to oral formulations, there is no standard dissolution method for assessing the dissolution behaviour of inhalable dry powder particles in the lungs. This review focuses on different dissolution systems and absorption models used to evaluate dry powder formulations. It includes an overview of airway epithelium as well as barriers to development. an in vitro dissolutio.. Read More»
  DOI: 10.37421/2472-1018.2022.8.165

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