Department of Physiology and Pharmacology, Griffith University, QLD 4222, Australia
Short Communication
Influence of 5-HT2 Receptor Blockade on Motor Unit Firing and Persistent Inward Currents in Humans during Voluntary Muscle Contraction
Author(s): Benjamin Kavanagh*
Serotonergic neuromodulation plays a role in enhancing voluntary muscle activation. However, the influence of the potential motoneuron receptor
candidate (5-HT2) on the firing rate and activation threshold of motor units (MUs) in humans remains uncertain. This study aimed to investigate the
impact of 5-HT2 receptor activity on human MU behavior during gradually increasing contractions of varying intensity. The tibialis anterior muscle's
high-density surface electromyography (HDsEMG) was recorded while participants performed ramped isometric dorsiflexions at 10%, 30%, 50%,
and 70% of their maximum voluntary contraction (MVC). MU characteristics were extracted from HDsEMG data collected from 11 young adults
(including four females) before and after taking either an 8 mg cyproheptadine dose or a placebo. Blocking 5-HT2 receptors led to a decrease in
MU discharge r.. Read More»
DOI:
10.37421/2684-494X.2023.8.71
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