Faculty of Medicine, Sanko University, Gaziantep, Turkey
Short Communication
Methylglyoxal Levels and Restless Leg Syndrome in Patients with Chronic Renal Failure
Author(s): Benlier N*
Restless leg syndrome occurs frequently among patients with end-stage renal disease. Although the
etiopathogenesis of restless leg syndrome has not been fully elucidated, advanced age, female gender, positive
family history, chronic renal failure, pregnancy and folic acid and iron deficiency have all been implicated. Recent
studies found a diminished ability of D2 receptors to bind ligands and reduced 18F-dopa uptake in the putamen
and striatum in patients with restless leg syndrome. A marked increase in the plasma concentrations of glycation
end-products was observed in uremic patients. Methylglyoxal is a major end-product of glycolysis. Methylglyoxal is
a reactive carbonyl species that is formed during glucose metabolism. Methylglyoxal may increase the dopamine
concentration and other toxic metabolites such as salsolinol in dopaminergic neurons and dopami.. Read More»
Molecular and Genetic Medicine received 3919 citations as per Google Scholar report
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