Department of Nephrology, University of Toronto, Toronto, Canada
Mini Review
Exercise in Diabetic Kidney Disease: Protective Effects and Molecular Mechanisms
Author(s): Berbert Terk*
Diabetic kidney disease represents a significant complication of diabetes mellitus, contributing to the escalating global burden of end-stage
renal disease. Exercise has emerged as a crucial non-pharmacological intervention for managing DKD, offering protective effects against its
development and progression. This article reviews the epidemiological evidence supporting the benefits of exercise in DKD and elucidates
the underlying molecular mechanisms involved. Epidemiological studies consistently demonstrate an inverse relationship between physical
activity levels and DKD risk, with regular exercise associated with improvements in renal function, reduction in albuminuria, and attenuation of
renal fibrosis. At the molecular level, exercise exerts multifaceted effects on key pathophysiological pathways implicated in DKD. These include
enhancing insulin sensitivit.. Read More»
DOI:
10.37421/2161-0959.2024.14.502
Journal of Nephrology & Therapeutics received 784 citations as per Google Scholar report
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