Molecular Biology: Open Access

Department of Bioengineering, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany

Publications

• Mini Review   
  Characterizing the Tertiary Structure of the Rift Valley Fever Virus L Protein
  Author(s): Bernhard Niko*
  
  Rift Valley Fever Virus (RVFV) is a significant pathogen known for causing severe febrile illness and hemorrhagic fever in humans and substantial economic losses in livestock. The virus is a member of the Phlebovirus genus in the Bunyaviridae family, with a segmented RNA genome that encodes essential proteins for viral replication and transcription. Among these, the L protein is a critical component of the viral RNA polymerase complex, responsible for synthesizing viral RNA. Despite its pivotal role, the detailed tertiary structure of the L protein remains poorly characterized. The primary objective of this study is to elucidate the tertiary structure of the RVFV L protein using a combination of structural biology techniques. By understanding the spatial arrangement of this protein, we aim to uncover its functional mechanisms and identify potential targets for .. Read More»
  DOI: 10.37421/2168-9547.2024.13.439

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