Faculty of Health Sciences, University of Bangui, Central African Republic
Research Article
Adverse Effects of First-Line Antiretroviral Therapy in Bangui
Author(s): Gaspard Tékpa*, Eudes Gbangba Ngai, Léon Kobangué, Christophe Landry Niko, Valentin Fikouma, Serges Magloire Camengo Police and Boniface Koffi
Objective: To describe the adverse effects of fixed combinations of antiretroviral drugs based on tenofovir+emtricit
abine+efavirenz (TDF/FTC/EFV) and zidovudine+lamivudine+nevirapine (AZT/3TC/NVP) and to identify the factors
associated with their occurrence.
Patients and methods: An analytical cross-sectional study included after informed consent people living with HIV
(PLHIVs). We used an exhaustive sampling by recruiting all the patients who came to get antiretroviral drugs during
the study period, aged at least 18 years, treated with TDF/FTC/EFV or AZT/3TC/NVP. Socio-demographic, clinical and
therapeutic data were collected, entered and analyzed with the software Epi-Info 7. The chi-square test was used to
compare the proportions with a significant level of 5%.
Results: A total of 282 patients wer.. Read More»
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