Journal of Interventional and General Cardiology

Department of Cardiology, Center for Molecular Cardiology, University of Zurich, Zurich, Switzerland

Publications

• Review Article   
  Patients Symptom of Underlying Cardiac Disease
  Author(s): Brian Olshansky*
  
  The description of atrial fibrillation (AF) as a functional electrical condition ignores the significant underlying structural abnormalities. The muscular sleeve of the atrium and the pulmonary vein (PV) undergo microstructural alterations, resulting in a weak foundation for AF maintenance. Current data indicate that this arrhythmia typically requires a trigger for start and a weak electrophysiological or anatomical substrate for maintenance, despite the lack of knowledge regarding the anatomical and functional foundations of AF. Whether the trigger mechanisms are focused improved automaticity, prompted activity, or micro re-entry from cardiac tissue is currently unknown. AF onset can be sped up by both sympathetic and parasympathetic stimuli, which appear to also play a role in AF maintenance. A mechanism that may involve cellular ageing, apoptosis, and .. Read More»
  DOI: 10.37421/2684-4591.2023.7.181

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