Journal of Immunobiology

Department of Molecular Immunology, University of Essex, Colchester, England

Publications

• Commentary   
  Macrophage Cell Biology from Development to Dysfunction in Inflammatory Diseases
  Author(s): Harriet Langford*, Callum Hargrove, Isla Pendleton, Rowan Tinsley and Beatrix Hammond
  
  Macrophages are fundamental components of the immune system, orchestrating responses to pathogens, maintaining tissue integrity, and mediating repair processes. These versatile cells arise from yolk sac progenitors or monocyte precursors, differentiating into tissue-resident macrophages influenced by local microenvironments. Their functional diversity enables macrophages to adopt specific roles, ranging from pathogen clearance to the regulation of inflammation. In inflammatory diseases, such as rheumatoid arthritis, atherosclerosis, and inflammatory bowel disease, macrophage dysfunction has emerged as a critical driver of pathogenesis. Dysregulation of their polarization into pro-inflammatory (M1) or anti-inflammatory (M2) phenotypes contributes to chronic inflammation and tissue damage. Additionally, alterations in macrophage metabolism and epigenetic profiles.. Read More»
  DOI: 10.37421/2476-1966.2024.9.243

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