Fluid Mechanics: Open Access

Department of Pharmaceutical Sciences, University of Geneva, 1211 Geneva, Switzerland

Publications

• Mini Review   
  Thermoresponsive Hydrogels Based on Hyaluronan for Injectable Use in Dermatology
  Author(s): Carriben Marsh*
  
  The majority of commercially available HA-based dermal fillers use chemical cross-linking to enhance their mechanical characteristics and prolong their shelf life in vivo; nevertheless, more rigid and elastic formulations need a stronger extrusion force for injection in clinical settings. We suggest a thermosensitive dermal filler, injectable as a low viscosity fluid that undergoes in-situ gelation upon injection, to balance longevity and injectability. In order to do this, "green chemistry" was used to combine HA with a linker and a thermosensitive polymer called poly(N-isopropylacrylamide) (pNIPAM). Water served as the solvent. At normal temperature, HA-L-pNIPAM hydrogels had a relatively low viscosity, but at body temperature, they spontaneously produced a stiffer gel with a submicron structure... Read More»
  DOI: 10.37421/2476-2296.2023.10.285

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