Journal of Food & Industrial Microbiology

Department of Bioinformatics, Bharathidasan University, Tamil Nadu, India

Publications

• Research Article   
  Functional Prediction and Assignment of Clostridium botulinum Type A1 Operome: A Quest for Prioritizing Drug Targets
  Author(s): Chellapandi P*, Roja B, Saranya S and Prathiviraj R
  
  Clostridium botulinum strain Hall is capable of producing a potent botulinum neurotoxin type A1 that causes food-borne, infant, and wound botulism in humans. Antibiotics and botulinum antitoxin are viable options for controlling growth and preventing botulinum intoxication in humans. The limited information on its proteins with unknown functions (operome or hypothetical proteins) hinders the discovery of new drug targets. Therefore, we aimed to apply a combined bioinformatics approach with literature support for the functional prediction, assignment, and validation of its operome. Our functional annotation scheme was based on sequence motifs, conserved domains, structures, protein folds, and evolutionary relationships of its operome. The precise functions of the 521 HPs (293 known) were annotated of which 293 HPs were previously annotated and 228 HPs not ann.. Read More»
  DOI: 10.37421/2572-4134.2024.10.301

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