Journal of Clinical Neurology and Neurosurgery

Department of Neurology, Sapienza University of Rome, 00161 Rome, Italy

Publications

• Mini Review   
  Navigating the Cognitive Terrain: Neurocognitive Changes in Patients Undergoing CAR-T Cell Therapy
  Author(s): Clamp Tanakabatiya*
  
  Chimeric Antigen Receptor T-cell (CAR-T cell) therapy has emerged as a groundbreaking treatment for hematologic malignancies, offering hope to patients with relapsed or refractory disease. While CAR-T cell therapy has demonstrated remarkable efficacy in inducing tumor remission, emerging evidence suggests potential neurocognitive changes as a consequence of treatment. In this review, we explore the landscape of neurocognitive changes in patients undergoing CAR-T cell therapy, focusing on the underlying mechanisms, clinical manifestations and implications for patient care. We discuss the multifactorial nature of neurocognitive changes, including Cytokine Release Syndrome (CRS), immune-mediated neurotoxicity and Central Nervous System (CNS) infiltration of CAR-T cells. Furthermore, we examine the challenges in assessing and monitoring neurocognitive function in t.. Read More»
  DOI: 10.37421/2684-6012.2024.7.230

  Abstract HTML PDF