Journal of Material Sciences & Engineering

Department of Surgery, South Texas Veterans Healthcare System, Texas, United States

Publications

• Full Length Research Paper   
  Electrospun Polyglycolic Acid-Poly(Carbonate-Urea) Urethane Scaffold as a Hybrid Tissue Engineered Vessel
  Author(s): Clay Quint*
  
  Alternative small diameter vascular grafts are needed for patients that require surgical revascularization in patients lacking autologous vein. In this study, a Polyglycolic Acid (PGA)-Thermoplastic Polyurethane (TPU) electrospun scaffold seeded with human dermal fibroblasts was placed in a biomimetic perfusion system to generate a hybrid tissue engineered vessel. The outer layer was an electrospun PGA that was co-electrosprayed with sacrificial polyethylene oxide (PEO) microparticles to increase porosity. The PGA-TPU scaffold remained static for 1 week, then circumferential strain amplitude was incremented from 1% to 5% over 6 weeks. The hybrid tissue engineered vessel had an outer cellular layer with collagen deposition replacing the biodegradable PGA and the inner residual polyurethane layer remained relatively acellular. The tensile properties of the hybrid tissue engineered vesse.. Read More»
  

  Abstract PDF