Department of Clinical Pediatrics, University of Milan, ASST Santi Paolo e Carlo, PO San Paolo,Via A. Di Rudinì, 8, 20142 Milan, Italy
Mini Review
Early Prevention of Atherosclerosis: Paediatric Aspects of Familial Hypercholesterolamia
Author(s): Cristina Pederiva, Valentina Rovelli and Giuseppe Banderali*
Familial Hypercholesterolaemia (FH) is the most common primitive cause of hypercholesterolaemia, affecting 1: 200-250 individuals and characterized by lifelong elevation of lowdensity
lipoprotein cholesterol (LDL-C) levels which significantly accelerate atherosclerosis. Early detection and treatment of hypercholesterolaemia in childhood can reduce the
impact on the cumulative life-burden of LDL cholesterol. In the last ten years, many screening strategies involving the whole family have been carried out: selective screening, cascade
screening, inverse screening, and universal screening. Blood lipid profile evaluation (total cholesterol, LDL-C, HDL-C and triglycerides) is the first step. It has to be ideally performed
between 2 and 10 years of age. Hypercholesterolaemia has to be confirmed with a second sample and followed by the detection of family history for premature (b.. Read More»
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