Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University, Kobe, Japan
Research
Fatty Acid-binding Protein 3 Knockout Mice Ameliorate High-fat Diet-induced Pain Exacerbation
Author(s): Dan Tachibana, Kazuo Nakamoto and Shogo Tokuyama*
Objective: Obesity is associated with the exacerbation of pain. Recently, it was reported that High-Fat Diet (HFD)-induced obese mice show
mechanical hypersensitivity after surgery, which causes neuroinflammation via microglial activation in the hypothalamus. However, the mechanism
by which HFD-induced obesity exacerbates pain remains unclear. The Fatty Acid-Binding Protein (FABP) 3 belongs to a family of proteins
that transports fatty acids into the cell and modulates cellular functions. We demonstrated that FABP3 was increased in the hypothalamus of
postoperative pain mice, and was co-expressed in microglia. FABP3 has a high affinity for saturated Fatty Acids (FAs) and n-6 polyunsaturated
FAs in HFD-fed mice, and its function is affected by different types of FAs. Here, we tested whether FABP3 is involved in the mechanism of obesityinduced
pa.. Read More»
DOI:
10.37421/2952-8100.2024.7.435
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