Department of Oncology, University of Oxford, Oxford, United Kingdom
Commentary
A RASSF1A as a Mechanosensitive Regulator of Cancer Stemness
Author(s): Daniela Pankova and Eric O Neill*
Population of cancer stem cells in solid tumors represents a major factor of resistance to conventional therapy that influences patient survival. We recently identify RASSF1A as a novel
regulator of cancer stemness that plays a key role in regulation of mechanical properties provided by ECM in lung cancer. We showed that epigenetic loss of RASSF1A promotes YAP1
nuclear accumulation which, via P4HA2 expression, drives ECM remodeling associated with Cancer Stem Cell (CSC) plasticity during malignant carcinogenesis... Read More»
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