Journal of Clinical Research

Department of Medical Informatics, Northwest Permanente, Portland, OR, USA

Publications

• Mini-Review   
  Glucocorticoid Induced Immune Modulations Molecular Biology to Clinical Research
  Author(s): Dean Sittig*
  
  For more than 70 years, glucocorticoids have been used to treat autoimmune and inflammatory diseases because of their potent anti-inflammatory and immune-suppressive properties. The severity of their side effects, which include osteoporosis, muscle wasting, hyperglycaemia, and hypertension, as well as the occurrence of resistance to glucocorticoid therapy, limit their use. An overview of our current understanding of the mechanisms underlying glucocorticoid treatments therapeutic and side effects, as well as the decreased sensitivity observed in resistant patients, is provided in this Special Issue. In addition, research that aims to either prevent or treat glucocorticoid resistance or to develop novel glucocorticoid therapies with fewer side effects is highlighted. The calming impacts of glucocorticoids are interceded by an intracellular receptor, the glucocort.. Read More»
  DOI: 10.37421/2795-6172.2022.6.173

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