Department of Medical Informatics, Northwest Permanente, Portland, OR, USA
Mini-Review
Glucocorticoid Induced Immune Modulations Molecular Biology to Clinical Research
Author(s): Dean Sittig*
For more than 70 years, glucocorticoids have been used to treat autoimmune and inflammatory diseases because of their potent anti-inflammatory
and immune-suppressive properties. The severity of their side effects, which include osteoporosis, muscle wasting, hyperglycaemia, and
hypertension, as well as the occurrence of resistance to glucocorticoid therapy, limit their use. An overview of our current understanding of
the mechanisms underlying glucocorticoid treatments therapeutic and side effects, as well as the decreased sensitivity observed in resistant
patients, is provided in this Special Issue. In addition, research that aims to either prevent or treat glucocorticoid resistance or to develop novel
glucocorticoid therapies with fewer side effects is highlighted. The calming impacts of glucocorticoids are interceded by an intracellular receptor,
the glucocort.. Read More»
DOI:
10.37421/2795-6172.2022.6.173
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