Journal of Pharmacognosy & Natural Products

Department of Pharmacognosy, Sree Sastha Pharmacy College, Chembarambakkam, Chennai, India

Publications

• Research Article   
  Antidepressant Activity of Embelin Isolated from the Methanol Extract of Fruits of Embelia ribes Burm
  Author(s): Dhanapal Venkatachalam*
  
  Objective: The objective of the study was to evaluate the major known active principle embelin of Embelia ribes for possible antidepressant activity. Embelia ribes Burm (Family: Myrsinaceae) is extensively used in Indian traditional medicine for treating various disease conditions including chronic inflammatory disorders, heart and urinary conditions, snake and insect bites and tumour. Methodology: Fractionation of the methanlic extract of dried powdered fruits using column chromatography over silica gel afforded embelin. Experimental depression was induced by subjecting mice to Tail Suspension Test (TST) and Forced Swimming Test (FST) experimental models. Intraperitonial administration of embelin (2.5 and 5 mg/kg) 30 min prior to induction of experimental depression resulted in dose-dependent reduction of immobility under .. Read More»
  DOI: 10.37421/2472-0992.2023.9.256

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