Journal of Computer Science & Systems Biology

State Key Laboratory of Microbial Metabolism, and College of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China

Publications

• Research Article   
  Identification of Novel Therapeutic Targets in Myelodysplastic Syndrome Using Protein-Protein Interaction Approach and Neural Networks
  Author(s): Ali A, Junaid M, Khan A, Kaushik AC, Mehmood A, Saleem S, Nangraj AS and Dong-Qing Wei*
  
  A Myelodysplastic syndrome (MDS) is a disorder characterized by active but ineffective hematopoiesis that leads to pancytopenia. MDS, also termed as myeloid neoplasms, is described by different level of cytopenia that is a different level of blood cells in the body. Various genes mutations have been reported to associate with MDS. To investigate the mechanisms at molecular level underlying MDS patients carrying genetic mutations, the gene expression profiles of MDS the patients were compared to that of healthy individuals and analyzed by bioinformatics tools. In biological networks, genes having important functional roles can be identified by a measure of the node. Networks of genes an in co-expression, candidate hubs also called extremely associated genes have been connected with the key disease-related pathway. Thus, this technique was used to discover th.. Read More»
  

  Abstract PDF