Department of Pharmaceutical Management and Regulatory Affairs, Pulla Reddy Institute of Pharmacy, Hyderabad, India
Research Article
Formulation and Evaluation of Press Coated Tablets for Pulsatile Drug Delivery
Author(s): Donthireddy Sushma*
The aim of present investigation is to develop press coated tablet, a dry-coated device for pulsatile drug delivery of a pain relieving drug using different hydrophilic and hydrophobic polymers. It is intended to be used mainly in the therapy of pain symptoms which depend on circadian rhythms. The drug delivery system will be designed to deliver the drug at such a time when it could be most needful to patient of rheumatoid arthritis and fibromyalgia [1]. It will be aimed to have a lag time of four hours so that, the system is taken at the bed time and expected to release the drug after a period of 4 hours at mid night time when such pain are at peak and disturbs sleep. Such time-controlled pulsatile drug delivery can be achieved mainly with cores containing Tapentadol hydrochloride as active agent. Core formulations, characterized by different release rates .. Read More»
DOI:
10.37421/bset.2021.8.119
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