Journal of Immunobiology

Department of Internal Medicine, Besancon University Hospital, Besancon, France

Publications

• Mini Review   
  Lung Carcinoma-associated Immunosuppression as a Risk Factor for Life-threatening Pulmonary Infections
  Author(s): Elly Hawthorne*
  
  Lung carcinoma is frequently accompanied by immunosuppression, a critical factor predisposing patients to life-threatening pulmonary infections. This review examines the mechanisms through which lung carcinoma-associated immunosuppression compromises host defenses, including impaired immune cell function, cytokine dysregulation, and disrupted mucosal barriers. The interplay between tumor microenvironment components such as regulatory T cells, myeloid-derived suppressor cells, and tumor-associated macrophages contributes significantly to immune evasion and susceptibility to infections. Furthermore, therapeutic interventions such as chemotherapy and immune checkpoint inhibitors exacerbate immunosuppression, further increasing infection risk. Understanding these mechanisms is crucial for developing targeted therapies and preventive strategies to mitigate infection.. Read More»
  DOI: 10.37421/2476-1966.2024.9.234

  Abstract HTML PDF