Journal of Brain Research

Department of Neurosurgery of Republican Research and Clinical Center of Neurology and Neurosurgery, Minsk, Belarus

Publications

• Research Article   
  A Novel Modell of Brain Cortex Water Metabolism Based on the Nanofluidic-domain Theory and its Biomedical Implications
  Author(s): Ernst Titovets* and Fr. Skoriny Str
  
  Brain Water Metabolism (BWM) is involved in intercellular communication, transit of substrates, gases, drug delivery, spreading of malignant tumors. Various neurological conditions are accompanied by impaired BWM (e.g. idiopathic normal pressure hydrocephalus, syringomyelia, migraine, stroke, Alzheimer’s disease, etc.) The Extracellular Fluid (ECF), surrounding the neurocytes and the glia, circulates in the nanodimentional Extracellular Space (ECS), where its flow obeys the slip-flow principles of nanofluidics. The conventional view argues, however, that the nanodimentional ECS presents a diffusion barrier where convention is prohibited. A computer model has been developed revealing new features of BWM. The references are also presented, listing the AQP4-targeted drugs to be used in the therapy of brain edema. The research results may find their use in wide a.. Read More»
  DOI: 10.37421/2684-4583.2024.7.244

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