Department of Pharmacy, Osmania University, Hyderabad, Telangana, India
Brief Report
Monitoring Drug-Induced Hepatic Steatosis: Challenges and Non-Invasive Methods
Author(s): Eshitha Athmakur*
Drug candidates can induce hepatic steatosis, which is characterized by the accumulation of lipids in liver cells without any other morphological
changes. Clinical studies have reported two types of fat deposition patterns: diffuse and non-diffuse. The diffuse pattern is more common, while the
non-diffuse pattern includes several subtypes such as geographic, focal, sub-capsular, multifocal, and perivascular patterns. Since drug-induced
hepatic steatosis can have limited safety margins, it is crucial to develop methods to monitor its occurrence and severity during preclinical and
clinical studies. However, liver biopsy, which is considered the gold standard for diagnosing hepatic steatosis, has several limitations, such as
invasiveness, risk of hemorrhage and morbidity, and sampling errors due to the heterogeneity of fat distribution in the liver. Therefore, liver b.. Read More»
DOI:
10.37421/2684-494X.2023.8.63
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