Department of Pharmacy, Osmania University, Hyderabad, Telangana, India
Brief Report
Addressing Drug-induced Hepatic Steatosis: Overcoming Obstacles with Non-invasive Approaches
Author(s): Eshitha Athmakur*
Drug candidates have the potential to trigger hepatic steatosis, a condition characterized by the accumulation of lipids in liver cells without observable
morphological alterations. Clinical investigations have identified two distinct fat deposition patterns: diffuse and non-diffuse. The more
prevalent diffuse pattern contrasts with the non-diffuse category, which encompasses various subtypes, including geographic, focal, sub-capsular,
multifocal, and perivascular patterns. Given the narrow safety margins associated with drug-induced hepatic steatosis, it is imperative to devise
means for monitoring its incidence and severity in both preclinical and clinical research settings. Nevertheless, the conventional gold standard
for diagnosing hepatic steatosis, liver biopsy, presents numerous drawbacks such as invasiveness, risk of bleeding and complications, as well as
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DOI:
10.37421/2684-494X.2023.8.93
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