Department of Clinical and Chemical Pathology, Faculty of Medicine, Alazhar Univeristy, Cairo, Egypt
Research Article
Clinical Utility of Anti-Carbamylated Protein Antibody as a New Marker in Seronegative Rheumatoid Arthritis
Author(s): El-Shorbagy MS, El-Saied AH, Essa KS and Awad MMA*
Introduction: The development of rheumatoid arthritis (RA) is associated with the formation of a wide spectrum
of autoantibodies, including rheumatoid factors (RFs) and anti-citrullinated protein antibodies (ACPAs). A family of
autoantibodies that recognize carbamylated proteins, Anti-CarP antibodies can be detected in sera of RA patients.
The aim of the present study was to evaluate the role of anticarbamylated protein antibody (Anti-CarP antibodies) in
diagnosis of seronegative (Negative RF and Negative ACCP) RA patients, in monitoring the severity of inflammation
and degree of associated joint damage.
Methodology: Our study included 60 patients with seronegative RA (4 males and 56 females), their ages ranged
between 29 and 70 years with a mean age of 48.5 ± 11.8 years, and 20 healthy controls of matched age an.. Read More»
Immunochemistry & Immunopathology received 174 citations as per Google Scholar report
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