Cancer Science & Therapy

Department of Pharmacology and Toxicology, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia

Publications

• Research   
  Expression of Embryonic Stem Cell Markers in Childhood Neuroblastoma and Glioblastoma Cancer Cell Lines
  Author(s): Mohammed Al Mohaini, Fatima Al Hejji, Zahrah Al Hamar, Salah A. Abohelaika, Fadhel A. Al Omar, Nasir Al Awwad, Ali H. Al Turaifi and Hussain R. Al Turaifi*
  
  Cancer in childhood ages have significant differences from adult cancer in the incidence rate, type and location of cancer, pathophysiology, progression of tumor, management plan and recurrence rate. Cancer stem cells (CSCs) theory hypothesize the presence of small subset of cells within tumor mass that have the ability to renew them cells and differentiate to multiple cell types. In addition, these cells resist conventional chemotherapy and give rise new tumor cells causing relapse and metastasis. We tried to study the expression of pluripotent transcription factors in childhood cancer cell lines. The pediatric cell line, SJ-GBM2 and LAN-5, were obtained from the Children's Oncology Group Cell Culture and Xenograft Repository. RNA is extracted from confluent cultured cells. RT-PCR reaction from both cDNA was done for embryonic and adult stem cell markers. .. Read More»
  DOI: 10.37421/1948-5956.2023.15.586

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