Molecular and Genetic Medicine

University of Southern Denmark, Center for Bioanalytical Sciences, Campusvej 55, 5230 Odense M, Denmark

Publications

• Research Article   
  Biomarkers for Development of Glucocorticoid-Induced Diabetes Mellitus - A Metabolomics-Based Prediction Model
  Author(s): Klarskov CK*, Havelund JF, Zegers FD, Færgeman NJ, Schultz HH, Persson F, Debrabant B, Bjergaard UP and Kristensen PL
  
  Background: Glucocorticoid-induced diabetes mellitus (GIDM) is a serious side effect of glucocorticoid (GC) treatment that is associated with both increased mortality and morbidity, but not all patients develop GIDM when treated with GC. The reason is not known, and clinical risk factors predictive of type 2 diabetes do not predict GIDM. Previous metabolomics studies have found specific metabolic disturbances prior to clinical type 2 diabetes. This could also be true for GIDM. The primary aim of this study was to investigate whether distinct metabolic patterns in patients treated with high dose GC can predict development of GIDM. Material and Methods: Serum from 116 patients about to be treated with or in the first days of treatment with high-dose GC (>100 mg prednisolone equivalent) was analyzed with liquid chromatography-mass spectrometry .. Read More»
  DOI: 10.37421/1747-0862.2020.14.461

  Abstract HTML PDF