Molecular and Genetic Medicine

Department of Cardiovascular, Respiratory, Nephrology, Anesthesiology and Geriatric Sciences, Sapienza University of Rome, Viale del Policlinico 155 - 00161 Rome, Italy

Publications

• Review Article   
  Myocardial Ischemia in Women When Genetic Susceptibility Matters
  Author(s): Severino P, D’Amato A, Pucci M, Mariani MV, Netti L, Infusino F, Mancone M and Fedele F*
  
  Ischemic heart disease is the most common cause of death in both female and male genders. Though coronary artery disease is the most common determinant of ischemia in males, women present more often chest pain associated with normal epicardial coronary arteries. In females, coronary microvascular dysfunction plays a key role in developing symptoms and imbalance between delivery and request of coronary blood flow. Coronary ion channels play a major role in the regulation of coronary blood flow. According to the epidemiological, pathophysiological and clinical differences between male and female genders in ischemic heart diseases, it is legitimate to suspect the possible impact of gender on modulating the effect of cardiovascular risk factors. Whereas it is well known the role of estrogens in cardiovascular system, the role of genetics it has never been exten.. Read More»
  

  Abstract PDF