Department of Sports Medicine, Ningbo University, Ningbo 315832, China
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Unravelling Osteoarthritis: Polyunsaturated Fatty Acids' Impact Revealed Through Mendelian Randomization
Author(s): Finch Lauren*
Osteoarthritis (OA) is a prevalent degenerative joint disorder affecting millions globally, characterized by the breakdown of cartilage and the
underlying bone. While various risk factors have been implicated, the role of dietary components, especially Polyunsaturated Fatty Acids (PUFAs),
in OA development remains a subject of debate. This article explores the impact of PUFAs on osteoarthritis through the lens of Mendelian
Randomization (MR), shedding light on the intricate relationships between genetics, diet and joint health. Osteoarthritis manifests as the gradual
degradation of joint tissues, primarily cartilage. The joints lose their ability to absorb shock and distribute load efficiently, leading to pain, stiffness
and reduced mobility. While age is a well-established risk factor, researchers have been exploring the contribution of genetic and environmental
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DOI:
10.37421/2161-0673.2023.13.337
Journal of Sports Medicine & Doping Studies received 1022 citations as per Google Scholar report