Molecular Biomarkers & Diagnosis

Department of Molecular Biology, University of Helsinki, Finland

Publications

• Mini Review   
  Insights of Metabolomics in Human Calcium Metabolism Disorders
  Author(s): Franck Mariana*
  
  Calcium is involved in many physiological processes, including intracellular signalling, metabolism regulation, muscle contraction, and gene expression. The majority of calcium in the human body (up to 99%) is found in bones as calcium hydroxyapatite [Ca10(PO4)6(OH)2], with less than 1% found in extracellular fluids. The most active form of calcium in extracellular fluids is the free ionised fraction, which directly interacts with calcium channels, calcium-sensing receptors (CaSRs), and cell membranes. The gastrointestinal tract, bones, and kidneys are primarily responsible for the physiological maintenance of calcium levels. The parathyroid gland produces parathormone (PTH), which regulates calcium within narrow limits by increasing calcium absorption in the intestine, bone-calcium mobilisation, and calcium reabsorption by the kidneys. Calcium ions are thought.. Read More»
  DOI: 10.37421/2155-9929.2022.13.534

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