Department of Nephrology, Tokyo Medical and Dental University, Tokyo, Japan
Mini Review
Unveiling Protein Kinase Signalling Components in the Renal Collecting Ducts
Author(s): Fumiaki Uchida*
Maintaining the equilibrium of bodily water involves a delicate interplay between water intake and excretion through processes such as urination,
defecation, perspiration, and respiration. Notably, elevated levels of the antidiuretic hormone vasopressin have been observed to reduce urine volume,
thereby preventing excessive loss of water from the system. The canonical pathway for this regulation occurs within the renal collecting ducts,
where vasopressin triggers a sequence involving cAMP and protein kinase A (PKA) signalling. This cascade culminates in the phosphorylation
of Aquaporin-2 (AQP2) water channels, facilitating the reabsorption of water from urine. While recent omics data have shed light on downstream
targets influenced by PKA, the pivotal regulators that oversee PKA-induced AQP2 phosphorylation remain elusive. A primary challenge arises from
the wi.. Read More»
DOI:
10.37421/2684-494X.2023.8.73
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