Journal of Computer Science & Systems Biology

Laboratory of Vascular Biochemistry, Institute of Genetics and Biochemistry, Federal University of Uberlândia, Campus Patos de Minas, Brazil

Publications

• Research Article   
  Conservation and Recombinational Contexts in Apoptosis Pathway in Aspergillus fumigatus
  Author(s): da Trindade NS, Santos Júnior CD, Macêdo PV, da Silva Viana J, Alves TC, Fürstenau CR, de Souza Gomes M and Enyara Rezende Morais*
  
  Introduction: Aspergillus fumigatus is a highly pathogenic fungus for immunocompromised patients and invasive aspergillosis exhibits mortality rates around 50-80%. Thus, the apoptosis pathway in this fungus may be an important target for the development of new drugs. Materials and Methods: From a data bank, we analyzed five different proteins (Bax, Bir, Nma111, Pca1, and Rad9) belonging to the apoptosis pathway in the genome of Aspergillus fumigatus. Phylogenetic trees, splits graphs, recombination analyses, and assessment of selection strength from codon to codon were developed to understand the evolution and the function of these proteins in the fungus. Results: Our results suggest a conservation of these proteins in the Aspergillaceae family, as well as a low rate of gene re.. Read More»
  

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