Journal of Clinical & Medical Genomics

Department of Genetics, University Medical Center Utrecht, Utrecht, Netherlands

Publications

• Mini Review   
  Strategies Based on Genes for Extended Lymphocytic Leukemia
  Author(s): Gatalica Zoran*
  
  Strategies based on genomic insights are increasingly becoming a cornerstone in the management of Chronic Lymphocytic Leukaemia (CLL), offering a more targeted and personalized approach to treatment. Genomic profiling has revealed a complex landscape of genetic alterations in CLL, guiding the development of innovative therapeutic strategies. One notable breakthrough involves the identification of specific genetic mutations, such as TP53, NOTCH1, and SF3B1, which are associated with distinct clinical behaviours and treatment responses. Tailoring therapeutic interventions based on the presence or absence of these mutations allows for a more nuanced prognosis and treatment plan. Precision medicine approaches, guided by genomic findings, have led to the development of novel targeted therapies that aim to disrupt specific molecular pathways involved in the progression of CLL. Burton’.. Read More»
  DOI: 10.37421/2472-128X.2023.11.254

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